TARGETED DESORPTION ELECTROSPRAY IONIZATION X-SPOT MASS SPECTROMETRY IMAGING (DESI XS MSI) INSTRUMENT

Procurement Summary

The acquisition of a targeted DESI XS MSI is crucial for the establishment of the Emerging Chemicals of Concern Program Area within CFSAN’s Office of Applied Research and Safety Assessment (ORSA), Division of Virulence Assessment (DVA). This advanced analytical tool allows for detailed imaging and analysis of chemical compounds directly on surfaces, particularly in complex samples such as plant tissues. The DESI XS MSI is a sophisticated analytical technique used to perform high-resolution imaging and analysis of chemical compounds directly on surfaces. This method allows for the detection and visualization of molecules in complex samples, such as plant tissues. When applied to assessing the presence of chemicals like Perfluoroalkyl Substances (PFAS), DESI XS MSI enables sensitive and specific detection of these compounds as they move within plant tissues from the soil or water sources during crop growth. DESI XS MSI functions by generating a charged aerosol of microdroplets that are sprayed onto a surface to desorb and ionize molecules for subsequent analysis by mass spectrometry. Notably, this technique requires minimal sample preparation, enabling the rapid detection and mapping of various compounds including chemicals, drugs, metabolites, and lipids in diverse sample types.

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