DOMESTICALLY MANUFACTURED ALLERGY DIAGNOTIC EQUIPMENT WITH A HIGH SPECIFICITY THROUGH MOLECULAR ALLERGENS AUTOMATIC PROCESSING SYSTEM (AMBIS 2231182)

Procurement Summary

The National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. Within the NIAID, the Laboratory of Clinical Immunology and Microbiology (LCIM) conducts clinical and basic science, and epidemiologic research into human immunologic, inflammatory, and infectious diseases. Primary immunodeficiencies (PIDs) that arise from a variety of mutations in genes involved in the immune system are a major focus area of the laboratory. To develop a comprehensive understanding of the natural history and pathogenesis of PIDs, the LCIM integrates clinical studies with laboratory investigations at molecular-, cellular-, and systems-level scales. Through exploiting knowledge gained in the clinic and in the laboratory, the LCIM aims to develop novel diagnostic methods and therapeutic approaches to manage and, ideally, cure patients of PIDs and infectious diseases. Description of the supplies or services to be purchased: Dr. Ian Myles ETU/LCIM; Building 298, Room 5NN24 will use the lgE assessment assay in his ongoing research under project # 147170 to identify activation pathways in the human and mouse immune systems. To continue to make scientific discoveries that promote the development of new vaccines, diagnostics, and therapeutics that improve human health. The current requirements are: 1. lmageXplorer Bundle, Item 87-IXBUNDLE-02, Qty 1 2. lmageXplorer with US Power Cord, Item 87-11-0000-02, Qty 1 3. Lab Rocker w/ U.S. Power Cord, Item 87-13-0000-00, Qty 1 4. ConfigXplorer (CX) Test Array, Item 87-30-0100-02, Qty 1 5. Array Holder, Item 87-14-0000-00, Qty 2 6. Incubation Chamber, Item 87-15-0000-00, Qty 1 7. Laptop, Item 06-LAPTOP, Qty 1 8. ALEX2 Allergy Explorer Kit (20 Tests), Item 87-02-2001-02, Qty 10 Specifications: • Fully automated or manual systems available. • Process 50/10 samples (automatically) or one sample manually in one run. • Samples per manual run 1. • Assay runs per day 2. • Max number of results/day 28.000. • Total assay time not to exceed 4.5 hours. • Hands on time not to exceed approx. 1 hour. • Power connection supply through USB port & US power cord. • Required sample volume 100 μl. • Allergy test Panel Kits (20 Tests) ○ ELISA-based IgE multiplex assay ○ 117 extracts & 178 molecular allergens ○ 50+ unique molecular allergens ○ Total IgE included. ○ Nonspecific IgE antibodies against cross-reactive carbohydrate determinants (CCDs) are automatically blocked. ○ High specificity & lower interpretative burden ○ Nano-bead technology ○ CCD-FREE DETECTION • Option for at least 15 predefined software panels (based on allergen groups) • Design your allergen panel via on-demand multiplex feature. • Incubation Chamber • Array Holder • Lab Rocker w/ U.S. power cord • Test Array Size requirements: (cannot exceed to fit in available lab space) • Net weight not to exceed 10 lbs – to easily be moved. • Width < 20 in, Depth < 20 in, Height < 20 in

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